Donker M, et al. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Abstract. JAMA Oncol. Krag D, et al. Spindle cell carcinoma of kidney, pelvis, ureter 20. It is open to women with a confirmed BRCA1 gene mutation who have not had a diagnosis of breast cancer. Study will last 3 months, 20 … 2014;15:1303–10. N Engl J Med. In addition to our many breast cancer trials, we offer trials for lung cancer, prostate cancer, ovarian cancer, and many more. Peritoneal mesothelioma (temporarily closed to accrual 05 / 08 / 2020) 41. Fisher B, et al. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. 2010;11(10):927–33. SUNNYVALE, Calif., Jan. 19, 2021 /PRNewswire/ -- Accuray Incorporated (NASDAQ: ARAY) announced today that data from a prospective, phase II trial of 338 women with low-risk breast cancer … Lancet. Pheochromocytoma, malignant (closed to accrual) 25. J Clin Oncol. Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10 / 17 / 2018) 7. The reader is encouraged to refer to the full manuscript of these trials for a greater understanding. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Location: 28 locations, This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors. Location: 544 locations, This randomized phase III trial studies if not giving regional radiotherapy is just as good as using regional radiotherapy in keeping breast cancer from coming back in patients with estrogen receptor (ER) positive, HER2 negative node positive low risk breast cancer who have undergone breast conserving surgery or mastectomy. It is not yet known if radiation therapy works better alone or with lymph node dissection in treating patients with breast cancer previously treated with chemotherapy and surgery. Location: 147 locations, This randomized phase III trial studies proton beam radiation therapy (proton therapy) compared to photon beam radiation therapy (photon therapy) in treating patients with breast cancer that has not spread to other places in the body (non-metastatic). Brief Summary: This Phase II will evaluate a new type of breast cancer … Not logged in About this trial Everyone in this trial had a single area of breast cancer … Location: 1372 locations, This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. This material is provided for educational purposes only and with the goal of encouraging further study about the landmark trials that have impacted oncology. Whelan T, et al. 2010;28:5132–9. The clinical trial will take place in three Canadian centers, including the Cross Cancer Institute in Edmonton, and will enroll patients with advanced and previously treated lymphoma, breast, … The reason for this study is to see if the study drug LY3484356 alone or in combination with other anticancer therapies is safe and effective in participants with advanced or metastatic breast cancer or endometrial cancer. This service is more advanced with JavaScript available, Landmark Trials in Oncology One exploratory single-agent atezolizumab (SAA) cohort may also be enrolled with CRPC subjects. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Patients will get T-DM1 injections from the study site staff on the first day of every cycle. The 2020 conference went online and saw a number of clinically significant results presented that will help inform the treatment of breast cancer in the clinic and guide further clinical trials. Clinical trials look at new ways to prevent, detect, or treat disease. Gestational trophoblastic disease (GTD) 47. Three studies are included that lessened the burden of surgery including the NSABP B-04, NSABP B-06, and NSABP B-32 trials. Background: Breast cancer patients have a lifelong 2-4-fold increased risk of developing a second primary tumor in the contralateral breast compared with the risk for a first primary breast cancer in the general female population. Location: 47 locations, This study looks at the risks and benefits of active monitoring (AM) compared to surgery in the setting of a pragmatic prospective randomized trial for low risk DCIS. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. In systemic management, an early trial by Bonadonna et al. Dale Shepard, MD, PhD: So in terms of reaching out specifically to patients within breast cancer trials and breast cancer care, how big of a role does social media, patient support groups, how big of a role does that play in terms of patient awareness of a trial … Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. Gastrointestinal stromal tumor (GIST) (closed to accrual 09 / 26 / 2018) 38. J Natl Cancer Inst. Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03 / 15 / 2019) 34. Lancet Oncol. 2014;383:2127–35. Treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) It is not known whether patients with low risk breast cancer need to receive regional radiotherapy. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Location: 848 locations, This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. PD-L1 amplified tumors 50. Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information. Regional nodal irradiation in early stage breast cancer. This is a blinded study, so neither patients nor their doctors will know whether a patient gets tucatinib or placebo. A 15-year meta-analysis conducted by the Early Breast Cancer Trialists’ Collaborative Group of long-term outcomes among 100,000 women treated in 123 randomized trials to evaluate polychemotherapy demonstrated a 10-year breast cancer … Earlier data from the trial, led to the FDA approval of the antibody-drug conjugate in December 2019 in adult patients with unresectable or metastatic HER2-positive breast cancer who … Ask whether the combination of drugs proposed for your chemotherapy have been through clinical trials The Early Breast Cancer Trialists’ Collaborative Group meta-analysis evaluated which patients benefited from postmastectomy radiation therapy. Bonadonna G, et al. Prevention of contralateral breast cancer … Many women will also receive radiotherapy to the whole breast / chest area and the surrounding lymph glands (called regional radiotherapy). The IES trial was designed as an international, multicenter, randomized, double‐blind trial to compare the efficacy and safety of continued adjuvant tamoxifen therapy with exemestane therapy in postmenopausal women with primary breast cancer … This chapter contains a summary of some key findings from a selection of 24 trials related to breast cancer. The clinical trials on this list are for breast cancer. The CALGB 9343 trial evaluated the role of post-lumpectomy radiation in an older population of ER-positive patients and is discussed. Citron M, et al. Trials have looked at hormone therapies including: 1. tamoxifen 2. raloxifene 3. anastrozole (Arimidex) The results show that these drugs can lower the risk of breast cancer in women at high risk. Adenoid cystic carcinoma (closed to accrual 02 / 06 / 2018) 35. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This is a preview of subscription content. Sarcomatoid carcinoma of lung 12. The clinical trial will take place in three Canadian centers, including the Cross Cancer Institute in Edmonton, and will enroll patients with advanced and previously treated lymphoma, breast, … (closed to accrual) 23. The study has randomized more than 10,200 women with this type of breast cancer at 1,182 sites in the … Previous studies have found that women who are overweight or obese when their breast cancer is found (diagnosed) have a greater risk of their breast cancer recurring, as compared to women who were thinner when their cancer … Endocrine therapy with fulvestrant prevents growth of hormone receptor positive breast cancer by blocking stimulation of tumor cells by estrogen. This trial is being done to find out whether addition of a platinum agent after completion of surgery will provide a higher disease free survival benefit than capecitabine in treating patients with residual triple-negative breast cancer. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Randomized data on chemoprevention • Prospective, double-blind, randomized trial • Involved 19,747 postmenopausal females and studied tamoxifen versus raloxifene in preventing breast cancer • The final analysis initiated after at least 327 incident invasive breast cancers were diagnosed: 163 and 168 cases of invasive breast cancer in tamoxifen and raloxifene treated groups • No differences were found for other invasive cancer … This trial was open for people to join between 2012 and 2015, and the team published the results in 2018. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. The FDA has approved a triple-negative breast cancer vaccine for use in human clinical trials. The dietary modification trial studied the effect of a diet low in fat and high in fruits, vegetables, and grains on the prevention of breast and colorectal cancer and heart disease. Location: 15 locations, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Weight Loss Interventions in Treating Overweight and Obese Women with a Higher Risk for Breast Cancer Recurrence, Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial), Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel with or without Carboplatin in Treating Patients with Triple-Negative Breast Cancer, Lymph Node Dissection and Radiation Therapy in Treating Patients with Breast Cancer Previously Treated with Chemotherapy and Surgery, Nivolumab and Ipilimumab in Treating Patients with Rare Tumors, Testing Platinum-based Chemotherapy after Surgery in Triple-Negative Breast Cancers, Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer, Testing the Ability to Decrease Chemotherapy in Patients with HER2-Positive Breast Cancer Who Have No Remaining Cancer at Surgery after Limited Pre-operative Chemotherapy and HER2-Targeted Therapy, Testing the Drug Atezolizumab or Placebo with Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer, Regional Radiation Therapy with or without Whole Breast Irradiation in Treating Patients with Estrogen Receptor Positive, HER2 Negative Low Risk Breast Cancer Who Have Undergone Breast Conserving Surgery or Mastectomy, Radiation Therapy with or without Olaparib in Treating Patients with Inflammatory Breast Cancer, Proton Beam Radiation Therapy or Photon Beam Radiation Therapy in Treating Patients with Non-Metastatic Breast Cancer, A Radiotherapy Comparative Effectiveness (RadComp) Consortium Trial, Olaparib with or without Atezolizumab in Treating Patients with Locally Advanced Unresectable or Metastatic Non-HER2-Positive Breast Cancer, Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS, Fulvestrant with or without Palbociclib and Avelumab in Treating Patients with Hormone Receptor Positive, HER2 Negative Metastatic or Recurrent Breast Cancer That Cannot Be Removed by Surgery Previously Treated with CDK and Endocrine Therapy, Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer, Trastuzumab, Vinorelbine Tartrate, and Avelumab with or without Utomilumab in Treating Patients with HER2-Positive Metastatic Breast Cancer, Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors, A Study of Tucatinib vs. Energy x-rays to kill tumor cells outcomes compared to the whole breast / area. 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